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Recalling that the basic formula for a bond forward is F S (1 T(R Yc)) (where S for a bond is the bond s price, and duration is a measure of a bond s price sensitivity), it is the carry component (the ST(R Yc) component) that affects the price sensitivity (or duration) of a forward transaction Note that because R and Yc tend to be small values, carry also will tend to be a small value Observe also that because carry is a function of time (T), the incremental duration contribution made by carry will shrink as the expiration date of the forward approaches, and eventually disappears altogether at the.

Here, a K=KI 2HA and c is the activity coefficient of the univalent ion. We can get K(2HA) from Eq. (7.19). If we obtain Kf(HA ) by some other means, we 2

1 2 3 4 yt = xt + xt + xt + xt , 1 0 1 0 ct+1 = (ct+1 , ct+1 ) = (st+1 , st+1 ) T1 (ct ) T2 (ct 1 ).

FIGURE 2.5 Upstream BPON frame format: (a) The xed case transmission as individual ATM cells, (b) the DBA case transmission as series of identically addressed long cell strings called T-Conts, and (c) use of one cell duration for a PLOAM cell.

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When the input feature is numerical, the p-fuzzy sets are used whose one-dimensional form with range [0,1] is as follows [equation (2.9)]: 8 2 > > 2 1 k Fj c k > for l k Fj c k l > 2 > l > < 2 3:34 p Fj ; c; l > 1 2 k Fj c k > for 0 k Fj c k l > 2 > l > > : 0 otherwise where l > 0 is the radius of the p-function with c as the central point. Note that features in linguistic and set forms can also be handled in this framework [42]. Output Representation Consider an l-class problem domain. The membership of the ith pattern in class k, lying in the range [0,1], is de ned as [23] e mik ^i 1 1 wik =fd fe 3:35

allograft rejection mechanisms The antigen-speci c response in sh does involve B-cells and T-cells, but there appear to be species-dependent differences in the nature and regulation of the speci c immune response in sh (Manning & Nakanishi, 1996) In contrast to mammals, the immunoglobulins of sh are primarily tetrameric (referred to as IgM, as the mammalian pentameric Ig) (Glynn & Pulsford, 1990) and there does not appear to be an evolution of different globulin classes in the course of an antigen-response (Kaattari & Piganelli, 1996) Some studies do indicate a diversity of Igs in sh and the question of the roles of different Igs during phases of infection or involvement in other immune responses still remains unresolved (Bang et al, 1996) 421.

The difference appears similar to that between an assertion and an argument. An argument, unlike an assertion, provides a reason for accepting it. Those reasons may be good or bad, strong or weak. By stating a fact the witness refers to something concrete, something which the judge or jury can imagine or envisage. It is likely to t within the judge s or jury s experience of the world. But an opinion, as understood here, is a naked statement of viewpoint. Unless the witness adds reasons for believing it to be correct, it will remain an opinion which the judge or jury is being asked to take on faith or to rely upon the reputation of the witness.

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3 Methods to study sh immune responses to xenobiotics The methods that have been used to identify effects of xenobiotics on sh immune response can be divided into three groups: non-speci c assays, speci c assays and either assay type used with antigen stimulation (Anderson, 1990) The non-speci c assays include hematocrit, leukocrit, the content of various classes of leukocytes and thrombocytes, general assays of macrophage function As the name implies, speci c assays are functions related to or responses to speci c antigens These include agglutination assays, mitotic response (proliferation of B-cells), reduced ability to synthesise antigen-speci c IgM and the ability to survive a challenge with a pathogen 4214 Natural modulation of the sh immune system In addition to pathogens, immune responses in sh are modulated by various endogenous and environmental factors, such as season, temperature, food availability, food quality, age and gender.

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